Search results for " phenotype III"

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Identification of Three Particular Morphological Phenotypes in Sporadic Thoracic Aortic Aneurysm: Phenotype III As Sporadic Thoracic Aortic Aneurysm …

2014

Abstract Aging has a striking impact on the heart and the vascular system, particularly on the large elastic arteries (i.e., aorta), resulting in a multitude of changes at different structural and functional levels. As result, medial degeneration (MD) occurs. A characteristic example of MD is sporadic thoracic aortic aneurysm (S-TAA), whose patho-physiological mechanisms remain unclear. In this study, typical MD morphological phenotypes were researched in S-TAA cases and control aorta specimens by histopathological and immunohistochemical analyses. Three phenotypes (I, II, and III) were detected, but mainly the phenotype III was observed. Elevated cystic MD, plurifocal medial apoptosis, and…

MalePathologymedicine.medical_specialtyAgingThoracicAging; Aorta; Aortic Aneurysm Thoracic; Biomarkers; Female; Humans; Male; Middle Aged; PhenotypeDissection (medical)Settore MED/08 - Anatomia PatologicaThoracic aortic aneurysmAneurysmmedicine.arteryMedicineHumansSettore MED/05 - Patologia ClinicaAortaSettore MED/04 - Patologia GeneraleAortaSurgical approachAortic Aneurysm Thoracicbusiness.industrySettore MED/23 - Chirurgia CardiacaMiddle Agedmedicine.diseaseTAA phenotype IIIPhenotypeAortic AneurysmPhenotypeImmunohistochemistryBiomarker (medicine)FemaleGeriatrics and GerontologybusinessBiomarkers
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A particular phenotype of ascending aorta aneurysms as precursor of type A aortic dissection.

2012

Objectives: We aimed to identify a phenotype of ascending thoracic aortic aneurysm (TAA), which, more than others, evolves into type A dissection (TAD). Methods: Aortic specimens were obtained from patients undergoing surgical repair of TAA and TAD (108 and 26, respectively). Histopathological and immunohistochemical analyses were performed by using adequate tissue specimens, appropriate techniques and criteria. Results: We identified the three following TAA phenotypes: phenotype I (cystic medial degeneration balanced by a substitutive fibrosis, in absence of medial apoptosis and with a faint collagenase concentration), phenotype II (cystic medial degeneration of higher grade, respectively,…

Pulmonary and Respiratory MedicineMalePathologymedicine.medical_specialtyAorta ThoracicApoptosisThoracic aortic aneurysmAortic aneurysmAneurysmFibrosismedicine.arteryAscending aortamedicineSettore MED/05 - Patologia ClinicaThoracic aortaHumansAgedAortic dissectionAortaAortic Aneurysm Thoracicbusiness.industryDissectionSettore MED/23 - Chirurgia CardiacaOriginal ArticlesMiddle Agedmedicine.diseasePrognosisAneurysmFibrosisImmunohistochemistryAortic DissectionPhenotypeMatrix Metalloproteinase 9Disease ProgressionSurgeryFemaleThoracic aortic aneurysm phenotype IIICardiology and Cardiovascular MedicinebusinessAneurysm ; Dissection ; Thoracic aortic aneurysm phenotype IIIBiomarkersInteractive cardiovascular and thoracic surgery
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